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Determination of novel CYP2D6 haplotype using the targeted sequencing followed by the long-read sequencing and the functional characterization in the Japanese population.
Fukunaga, Koya; Hishinuma, Eiji; Hiratsuka, Masahiro; Kato, Ken; Okusaka, Takuji; Saito, Takeo; Ikeda, Masashi; Yoshida, Teruhiko; Zembutsu, Hitoshi; Iwata, Nakao; Mushiroda, Taisei.
Afiliação
  • Fukunaga K; Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Hishinuma E; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Hiratsuka M; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Kato K; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
  • Okusaka T; Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
  • Saito T; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Ikeda M; Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku University, Sendai, Japan.
  • Yoshida T; Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan.
  • Zembutsu H; Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Iwata N; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Tokyo, Japan.
  • Mushiroda T; Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
J Hum Genet ; 66(2): 139-149, 2021 Feb.
Article em En | MEDLINE | ID: mdl-32759992
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamoxifeno / Haplótipos / Citocromo P-450 CYP2D6 / Sequenciamento de Nucleotídeos em Larga Escala / Fibroblastos / Transtornos Mentais / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tamoxifeno / Haplótipos / Citocromo P-450 CYP2D6 / Sequenciamento de Nucleotídeos em Larga Escala / Fibroblastos / Transtornos Mentais / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article