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Annulation reaction enables the identification of an exocyclic amide tricyclic chemotype as retinoic acid Receptor-Related orphan receptor gamma (RORγ/RORc) inverse agonists.
Marcoux, David; Bertrand, Myra Beaudoin; Weigelt, Carolyn A; Yip, Shiuhang; Galella, Michael; Park, Hyunsoo; Wu, Dauh-Rurng; Wang, Jinhong; Yarde, Melissa; Cvijic, Mary Ellen; Li, Sha; Hynes, John; Tino, Joseph A; Zhao, Qihong; Dhar, T G Murali.
Afiliação
  • Marcoux D; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States. Electronic address: david.marcoux.1@gmail.com.
  • Bertrand MB; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Weigelt CA; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Yip S; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Galella M; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Park H; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Wu DR; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Wang J; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Yarde M; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Cvijic ME; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Li S; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Hynes J; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Tino JA; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Zhao Q; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States.
  • Dhar TGM; Research and Early Development, Bristol Myers Squibb, 3551 Lawrenceville Rd, Princeton, NJ 08540, United States. Electronic address: murali.dhar@bms.com.
Bioorg Med Chem Lett ; 30(19): 127466, 2020 10 01.
Article em En | MEDLINE | ID: mdl-32763309
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Amidas / Hidrocarbonetos Cíclicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfonas / Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares / Amidas / Hidrocarbonetos Cíclicos Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article