Donor-derived Cell-free DNA in Infections in Kidney Transplant Recipients: Case Series.
Transplant Direct
; 6(7): e568, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32766423
ABSTRACT
BACKGROUND:
Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive plasma biomarker to evaluate for transplant allograft rejection. The relationship between infectious complications in kidney allografts and dd-cfDNA has received cursory attention in prior publications.METHODS:
Retrospective review of all renal transplant recipients who underwent dd-cfDNA testing between November 2017 and August 2019.RESULTS:
We report on 7 cases in whom infections affecting the transplanted kidney were associated with elevation in dd-cfDNA without concomitant rejection or elevation in serum creatinine. Five patients had BK viremia, and 2 patients had urinary tract infection associated with elevated dd-cfDNA levels.CONCLUSIONS:
These observations suggest that elevations in dd-cfDNA are not specific to kidney allograft rejection and can be associated with infections affecting the transplanted kidney. This biomarker may be valuable in evaluating infectious complications of kidney allografts.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article