ISL1 loss-of-function variation causes familial atrial fibrillation.

Wu, Shao-Hui; Wang, Xin-Hua; Xu, Ying-Jia; Gu, Jia-Ning; Yang, Chen-Xi; Qiao, Qi; Guo, Xiao-Juan; Guo, Yu-Han; Qiu, Xing-Biao; Jiang, Wei-Feng; Yang, Yi-Qing

Wu, Shao-Hui; Wang, Xin-Hua; Xu, Ying-Jia; Gu, Jia-Ning; Yang, Chen-Xi; Qiao, Qi; Guo, Xiao-Juan; Guo, Yu-Han; Qiu, Xing-Biao; Jiang, Wei-Feng; Yang, Yi-Qing.

Afiliação

Wu SH; Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Wang XH; Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Xu YJ; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Gu JN; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Yang CX; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Qiao Q; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Guo XJ; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Guo YH; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Qiu XB; Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jiang WF; Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: jiang_weifeng@sina.cn.
Yang YQ; Department of Cardiology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Cardiovascular Research Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China; Central Laboratory, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China. Electronic

Eur J Med Genet ; 63(11): 104029, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32771629

Assuntos

Fibrilação Atrial/genética; Proteínas com Homeodomínio LIM/genética; Mutação com Perda de Função; Fatores de Transcrição/genética; Adulto; Idoso; Fibrilação Atrial/patologia; Códon sem Sentido; Feminino; Fator de Transcrição GATA4/genética; Fator de Transcrição GATA4/metabolismo; Células HEK293; Proteína Homeobox Nkx-2.5/genética; Proteína Homeobox Nkx-2.5/metabolismo; Humanos; Proteínas com Homeodomínio LIM/metabolismo; Fatores de Transcrição MEF2/genética; Fatores de Transcrição MEF2/metabolismo; Masculino; Pessoa de Meia-Idade; Linhagem; Proteínas com Domínio T/genética; Proteínas com Domínio T/metabolismo; Fatores de Transcrição/metabolismo

Palavras-chave

Atrial fibrillation; Medical genetics; Reporter gene analysis; Transcription factor; Whole exome sequencing

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Fatores de Transcrição / Proteínas com Homeodomínio LIM / Mutação com Perda de Função Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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