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Tandem-Mass-Tag Based Proteomic Analysis Facilitates Analyzing Critical Factors of Porous Silicon Nanoparticles in Determining Their Biological Responses under Diseased Condition.
Li, Yunzhan; Liu, Zehua; Li, Li; Lian, Wenhua; He, Yaohui; Khalil, Elbadry; Mäkilä, Ermei; Zhang, Wenzhong; Torrieri, Giulia; Liu, Xueyan; Su, Jingyi; Xiu, Yuanming; Fontana, Flavia; Salonen, Jarno; Hirvonen, Jouni; Liu, Wen; Zhang, Hongbo; Santos, Hélder A; Deng, Xianming.
Afiliação
  • Li Y; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • Liu Z; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Li L; Drug Research program Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki Helsinki FI-00014 Finland.
  • Lian W; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • He Y; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Khalil E; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • Mäkilä E; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Zhang W; School of Pharmaceutical Sciences Xiamen University Fujian 361101 China.
  • Torrieri G; Drug Research program Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki Helsinki FI-00014 Finland.
  • Liu X; Laboratory of Industrial Physics Department of Physics University of Turku Turku FI-20014 Finland.
  • Su J; Department of Chemistry University of Helsinki Helsinki FI-00014 Finland.
  • Xiu Y; Drug Research program Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki Helsinki FI-00014 Finland.
  • Fontana F; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • Salonen J; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Hirvonen J; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • Liu W; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Zhang H; State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling Network School of Life Sciences Xiamen University Fujian 361101 China.
  • Santos HA; State-Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University Fujian 361101 China.
  • Deng X; Drug Research program Division of Pharmaceutical Chemistry and Technology Drug Research Program Faculty of Pharmacy University of Helsinki Helsinki FI-00014 Finland.
Adv Sci (Weinh) ; 7(15): 2001129, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32775170
The analysis of nanoparticles' biocompatibility and immunogenicity is mostly performed under a healthy condition. However, more clinically relevant evaluation conducted under pathological condition is less known. Here, the immunogenicity and bio-nano interactions of porous silicon nanoparticles (PSi NPs) are evaluated in an acute liver inflammation mice model. Interestingly, a new mechanism in which PSi NPs can remit the hepatocellular damage and inflammation activation in a surface dependent manner through protein corona formation, which perturbs the inflammation by capturing the pro-inflammatory signaling proteins that are inordinately excreted or exposed under pathological condition, is found. This signal sequestration further attenuates the nuclear factor κB pathway activation and cytokines production from macrophages. Hence, the study proposes a potential mechanism for elucidating the altered immunogenicity of nanomaterials under pathological conditions, which might further offer insights to establish harmonized standards for assessing the biosafety of biomaterials in a disease-specific or personalized manner.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article