Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance.

Wan, Jingjing; Qin, Zhen; Lei, Hong; Wang, Pengyuan; Zhang, Yu; Feng, Jiayi; Wei, Jie; Sun, Yang; Liu, Xia

Wan, Jingjing; Qin, Zhen; Lei, Hong; Wang, Pengyuan; Zhang, Yu; Feng, Jiayi; Wei, Jie; Sun, Yang; Liu, Xia.

Afiliação

Wan J; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Qin Z; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Lei H; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Wang P; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Zhang Y; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Feng J; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Wei J; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China.
Sun Y; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address: DawnySun@126.com.
Liu X; Department of Clinical Pharmacy, School of Pharmacy, Second Military Medical University, Shanghai, 200433, China. Electronic address: lxflying@aliyun.com.

Pharmacol Res ; 161: 105118, 2020 11.

Article em En | MEDLINE | ID: mdl-32777256

Assuntos

Metabolismo Energético/efeitos dos fármacos; Eritromicina/farmacologia; Fadiga Muscular/efeitos dos fármacos; Músculo Esquelético/efeitos dos fármacos; Orosomucoide/metabolismo; Resistência Física/efeitos dos fármacos; Proteínas Quinases Ativadas por AMP/metabolismo; Trifosfato de Adenosina/metabolismo; Animais; Linhagem Celular; Regulação da Expressão Gênica; Glicogênio/metabolismo; Humanos; Masculino; Camundongos Endogâmicos C57BL; Mitocôndrias Musculares/efeitos dos fármacos; Mitocôndrias Musculares/metabolismo; Músculo Esquelético/metabolismo; Orosomucoide/genética; Receptores CCR5/metabolismo; Corrida; Transdução de Sinais; Natação; Fatores de Tempo

Palavras-chave

AMPK; C-C motif chemokine receptor 5 (CCR5); erythromycin; glycogen; muscle endurance; orosomucoid (ORM)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência Física / Orosomucoide / Eritromicina / Músculo Esquelético / Fadiga Muscular / Metabolismo Energético Tipo de estudo: Guideline Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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