The co-deposition coating of collagen IV and laminin on hyaluronic acid pattern for better biocompatibility on cardiovascular biomaterials.

ABSTRACT

Construct a coating to repair the endothelium function is the ordinary and effective method to get out of the troubles which introduced by the cardiovascular implant devices. It indeed has plenty works on function construction which could inhibit the hyperplasia or accelerate the endothelialization with different functional proteins or molecules. However, a complete and healthy endothelium couldn't survive without the environment around. Thus, a logical biomimetic reconstruction with structure and function factors which using hyaluronic acid patterns to imitate the blood flow shear stress and co-depositing collagen type IV and laminin to achieve the biofunction of basement membrane had been proposed and realized in this work. After the tests of hemocompatibility, cytocompatibility and tissue compatibility, it had been indicated that this biomimetic coating could inhibit the adhesion of platelets, promote the proliferation and biofunction of endothelium cells, regulate smooth muscle cells with contractile phenotype and have much lower inflammatory response which might be a meaningful strategy on reconstruction and repairing of endothelium.