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Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Trypanosoma brucei Inhibitors.
Singh, Baljinder; Diaz-Gonzalez, Rosario; Ceballos-Perez, Gloria; Rojas-Barros, Domingo I; Gunaganti, Naresh; Gillingwater, Kirsten; Martinez-Martinez, Maria Santos; Manzano, Pilar; Navarro, Miguel; Pollastri, Michael P.
Afiliação
  • Singh B; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Diaz-Gonzalez R; Instituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18016, Spain.
  • Ceballos-Perez G; Instituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18016, Spain.
  • Rojas-Barros DI; Instituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18016, Spain.
  • Gunaganti N; Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
  • Gillingwater K; Parasite Chemotherapy Unit, Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland.
  • Martinez-Martinez MS; University of Basel, Petersplatz 1, 4001 Basel, Switzerland.
  • Manzano P; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Tres Cantos 28760, Spain.
  • Navarro M; Tres Cantos Medicines Development Campus, DDW, GlaxoSmithKline, Tres Cantos 28760, Spain.
  • Pollastri MP; Instituto de Parasitología y Biomedicina "López-Neyra" Consejo Superior de Investigaciones Científicas (CSIC), Granada 18016, Spain.
J Med Chem ; 63(17): 9912-9927, 2020 09 10.
Article em En | MEDLINE | ID: mdl-32786222
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Tripanossomicidas / Trypanosoma brucei brucei Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Tripanossomicidas / Trypanosoma brucei brucei Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article