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Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)-ones as Polypharmacological Inhibitors of BET and Kinases.
Lv, Kaikai; Chen, Weicong; Chen, Danqi; Mou, Jie; Zhang, Huijie; Fan, Tiantian; Li, Yanlian; Cao, Danyan; Wang, Xin; Chen, Lin; Shen, Jingkang; Pei, Dongsheng; Xiong, Bing.
Afiliação
  • Lv K; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Chen W; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
  • Chen D; Department of Pathology, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221006, China.
  • Mou J; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Zhang H; Jiangsu Key Laboratory of New Drug and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, 209 Tongshan Road, Xuzhou 221006, China.
  • Fan T; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Li Y; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
  • Cao D; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Wang X; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.
  • Chen L; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Shen J; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Pei D; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
  • Xiong B; Department of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China.
J Med Chem ; 63(17): 9787-9802, 2020 09 10.
Article em En | MEDLINE | ID: mdl-32787081
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Desenho de Fármacos / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinoxalinas / Desenho de Fármacos / Inibidores de Proteínas Quinases Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article