Prediction and evaluation of deleterious and disease causing non-synonymous SNPs (nsSNPs) in human NF2 gene responsible for neurofibromatosis type 2 (NF2).

Havranek, Brandon; Islam, Shahidul M

Havranek, Brandon; Islam, Shahidul M.

Afiliação

Havranek B; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, USA.
Islam SM; Department of Chemistry, University of Illinois at Chicago, Chicago, IL, USA.

J Biomol Struct Dyn ; 39(18): 7044-7055, 2021 11.

Article em En | MEDLINE | ID: mdl-32787631

Assuntos

Neurofibromatose 2; Neurofibromina 2; Polimorfismo de Nucleotídeo Único; Genes da Neurofibromatose 2; Humanos; Simulação de Dinâmica Molecular; Neurofibromatose 2/genética; Neurofibromina 2/genética; Proteínas Serina-Treonina Quinases; Proteínas Supressoras de Tumor

Palavras-chave

Hippo signaling pathway; Neurofibromatosis type 2 (NF2); binding affinity; flexibility; hydrogen bonding; merlin FERM domain protein; molecular docking; molecular dynamics simulation; mutations; single nucleotide polymorphism (SNP)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neurofibromatose 2 / Polimorfismo de Nucleotídeo Único / Neurofibromina 2 Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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