Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor &#945; expression.

Long, Xinyu; Gao, Yanfang; Liu, Weiwei; Liu, Xiaoling; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Ikejima, Takashi

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression.

Long, Xinyu; Gao, Yanfang; Liu, Weiwei; Liu, Xiaoling; Hayashi, Toshihiko; Mizuno, Kazunori; Hattori, Shunji; Ikejima, Takashi.

Afiliação

Long X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
Gao Y; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
Liu W; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
Liu X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
Hayashi T; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, People's Republic of China.
Mizuno K; Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665-1, Nakanomachi, Hachioji, Tokyo, 192-0015, Japan.
Hattori S; Nippi Research Institute of Biomatrix, Ibaraki, 649-1211, Japan.
Ikejima T; Nippi Research Institute of Biomatrix, Ibaraki, 649-1211, Japan.

Mol Cell Biochem ; 474(1-2): 243-261, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32789659

Assuntos

Diferenciação Celular; Movimento Celular; Receptor alfa de Estrogênio/antagonistas & inibidores; Regulação da Expressão Gênica/efeitos dos fármacos; Desenvolvimento Muscular; Mioblastos/fisiologia; Espécies Reativas de Oxigênio/metabolismo; Silibina/farmacologia; Animais; Antineoplásicos Fitogênicos/farmacologia; Proliferação de Células; Células Cultivadas; Receptor alfa de Estrogênio/genética; Receptor alfa de Estrogênio/metabolismo; Camundongos; Mioblastos/citologia; Mioblastos/efeitos dos fármacos

Palavras-chave

C2C12 cells; Estrogen receptors (ERs); Migration; Myogenic differentiation; ROS; Silibinin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diferenciação Celular / Movimento Celular / Regulação da Expressão Gênica / Espécies Reativas de Oxigênio / Desenvolvimento Muscular / Mioblastos / Receptor alfa de Estrogênio / Silibina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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