Relationship between antofloxacin concentration and QT prolongation and estimation of the possible false-positive rate.

Liang, Li-Yu; He, Ying-Chun; Li, Yun-Fei; Yang, Juan; Xu, Feng-Yan; Li, Lu-Jin; Huang, Ji-Han; Wang, Kun; Zheng, Qing-Shan

Liang, Li-Yu; He, Ying-Chun; Li, Yun-Fei; Yang, Juan; Xu, Feng-Yan; Li, Lu-Jin; Huang, Ji-Han; Wang, Kun; Zheng, Qing-Shan.

Afiliação

Liang LY; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
He YC; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Li YF; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Yang J; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Xu FY; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Li LJ; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Huang JH; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: huangjihan@shutcm.edu.cn.
Wang K; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: kunwang@139.com.
Zheng QS; Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address: qingshan.zheng@drugchina.net.

Biomed Pharmacother ; 130: 110619, 2020 Oct.

Article em En | MEDLINE | ID: mdl-32795925

Assuntos

Antibacterianos/efeitos adversos; Antibacterianos/farmacocinética; Síndrome do QT Longo/induzido quimicamente; Ofloxacino/análogos & derivados; Adulto; Estudos Cross-Over; Relação Dose-Resposta a Droga; Método Duplo-Cego; Eletrocardiografia/efeitos dos fármacos; Reações Falso-Positivas; Feminino; Voluntários Saudáveis; Frequência Cardíaca/efeitos dos fármacos; Humanos; Masculino; Modelos Estatísticos; Moxifloxacina/efeitos adversos; Moxifloxacina/farmacocinética; Ofloxacino/efeitos adversos; Ofloxacino/farmacocinética; Adulto Jovem

Palavras-chave

Antofloxacin; False-positive rate; Population modeling; QT interval prolongation; Thorough QT study

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do QT Longo / Ofloxacino / Antibacterianos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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