Super-enhancer-driven AJUBA is activated by TCF4 and involved in epithelial-mesenchymal transition in the progression of Hepatocellular Carcinoma.

Zhang, Chi; Wei, Shi; Sun, Wei-Peng; Teng, Kai; Dai, Miao-Miao; Wang, Feng-Wei; Chen, Jie-Wei; Ling, Han; Ma, Xiao-Dan; Feng, Zi-Hao; Duan, Jin-Ling; Cai, Mu-Yan; Xie, Dan

Zhang, Chi; Wei, Shi; Sun, Wei-Peng; Teng, Kai; Dai, Miao-Miao; Wang, Feng-Wei; Chen, Jie-Wei; Ling, Han; Ma, Xiao-Dan; Feng, Zi-Hao; Duan, Jin-Ling; Cai, Mu-Yan; Xie, Dan.

Afiliação

Zhang C; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Wei S; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Sun WP; Department of Anorectal Surgery, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China.
Teng K; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, 271000, Jinan, China.
Dai MM; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Wang FW; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Chen JW; Department of Pathology, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Ling H; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Ma XD; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Feng ZH; Department of Urology, First Affiliated Hospital, Sun Yat-sen University, 510060, Guangzhou, China.
Duan JL; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Cai MY; Department of Pathology, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.
Xie D; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 510060, Guangzhou, China.

Theranostics ; 10(20): 9066-9082, 2020.

Article em En | MEDLINE | ID: mdl-32802179

Assuntos

Carcinoma Hepatocelular/genética; Transição Epitelial-Mesenquimal/genética; Proteínas com Domínio LIM/genética; Neoplasias Hepáticas/genética; Fator de Transcrição 4/genética; Animais; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Movimento Celular/genética; Progressão da Doença; Feminino; Regulação Neoplásica da Expressão Gênica/genética; Células Hep G2; Humanos; Neoplasias Hepáticas/patologia; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; Pessoa de Meia-Idade; Oncogenes/genética; Fator 6 Associado a Receptor de TNF/genética

Palavras-chave

AJUBA; EMT; TCF4; hepatocellular carcinoma; super-enhancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Transição Epitelial-Mesenquimal / Proteínas com Domínio LIM / Fator de Transcrição 4 / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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