Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.
ChemMedChem
; 15(24): 2513-2520, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-32812371
ABSTRACT
Combined photochemical arylation, "nuisance effect" (SN Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination. Reactions were deliberately allowed to run "out of control" in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with SN Ar processes. As a result, a number of crystallographic hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Derivados de Benzeno
/
Inibidores Enzimáticos
/
Bibliotecas de Moléculas Pequenas
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article