The neural cell adhesion molecule (NCAM) as a regulator of cell-cell interactions.
Science
; 240(4848): 53-7, 1988 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-3281256
ABSTRACT
The neural cell adhesion molecule (NCAM) can influence a number of diverse intercellular events, including junctional communication, the association of axons with pathways and targets, and signals that alter levels of neurotransmitter enzymes. These pleiotropic effects appear to reflect the ability of NCAM to regulate membrane-membrane contact required to initiate specific interactions between other molecules. Such regulation can occur through changes in either NCAM expression or the molecule's content of polysialic acid (PSA). When NCAM with a low PSA content is expressed, adhesion is increased and contact-dependent events are triggered. In contrast, the large excluded volume of NCAM PSA can inhibit cell-cell interactions through hindrance of overall membrane apposition.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comunicação Celular
/
Antígenos de Superfície
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article