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Acromegaly accompanied by diabetes mellitus and polycystic kidney disease.
Otani, Daisuke; Murakami, Takaaki; Matsubara, Takeshi; Hojo, Masato; Nakae, Takuro; Moriyoshi, Koki; Yasoda, Akihiro; Usui, Ryota; Tatsuoka, Hisato; Ogura, Masahito; Inagaki, Nobuya; Yamamoto, Taizou.
Afiliação
  • Otani D; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Murakami T; Department of Diabetes and Endocrinology, Shiga General Hospital, Moriyama, Japan.
  • Matsubara T; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Hojo M; Department of Diabetes and Endocrinology, Shiga General Hospital, Moriyama, Japan.
  • Nakae T; Department of Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Moriyoshi K; Department of Neurosurgery, Shiga General Hospital, Moriyama, Japan.
  • Yasoda A; Department of Neurosurgery, Shiga General Hospital, Moriyama, Japan.
  • Usui R; Department of Diagnostic Pathology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Tatsuoka H; Clinical Research Center, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
  • Ogura M; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Inagaki N; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Yamamoto T; Department of Diabetes, Endocrinology and Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Endocr J ; 68(1): 103-110, 2021 Jan 28.
Article em En | MEDLINE | ID: mdl-32814722
Acromegaly is characterized by autonomous excessive growth hormone (GH) secretion, generally due to GH-producing pituitary adenoma, and is associated with various systemic comorbidities including diabetes mellitus. Polycystic kidney disease (PKD) is characterized by the growth of numerous cysts in the kidneys that deteriorate renal function. While possible renal effects of excessive GH exposure have been a current issue in experimental medicine, only five cases of coexisting acromegaly and PKD have been reported previously, and little is known regarding the influence of acromegaly on renal disease. We treated a 50-year-old male with diabetes mellitus who showed a sudden and rapid decline of renal function along with increasing proteinuria, which led to diagnoses of PKD and acromegaly. His urinary protein levels were increased together with excessive GH secretion and worsening glycemic control. An increase of total kidney volume was also noted. Transsphenoidal surgery for the pituitary adenoma was successfully performed. Marked improvement of hyperglycemia and proteinuria were observed after the surgery, but renal function was unchanged. The patient's clinical course suggested common aspects of excessive GH secretion as an accelerating factor of the progression of diabetic nephropathy and PKD via direct and indirect pathways. Although coexisting acromegaly and PKD is clinically rare, vigilance for early diagnosis of acromegaly is appropriate in patients with diabetes and/or PKD, especially in those showing unexpected exacerbation of renal dysfunction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acromegalia / Complicações do Diabetes / Doenças Renais Policísticas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acromegalia / Complicações do Diabetes / Doenças Renais Policísticas Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2021 Tipo de documento: Article