Metabolomics approach revealed robust changes in amino acid and biogenic amine signatures in patients with schizophrenia in the early course of the disease.

Parksepp, Madis; Leppik, Liisa; Koch, Kadri; Uppin, Kärt; Kangro, Raul; Haring, Liina; Vasar, Eero; Zilmer, Mihkel

Parksepp, Madis; Leppik, Liisa; Koch, Kadri; Uppin, Kärt; Kangro, Raul; Haring, Liina; Vasar, Eero; Zilmer, Mihkel.

Afiliação

Parksepp M; Department of Psychiatry, Institute of Clinical Medicine, University of Tartu, 31 Raja Street, 50417, Tartu, Estonia.
Leppik L; Psychiatry Clinic of Viljandi Hospital, 6 Pargi tee Street, 71024, Viljandi County, Estonia.
Koch K; Psychiatry Clinic of Viljandi Hospital, 6 Pargi tee Street, 71024, Viljandi County, Estonia.
Uppin K; Psychiatry Clinic of Tartu University Hospital, 31 Raja Street, 50417, Tartu, Estonia.
Kangro R; Psychiatry Clinic of Tartu University Hospital, 31 Raja Street, 50417, Tartu, Estonia.
Haring L; Institute of Mathematics and Statistics, University of Tartu, 18 Narva mnt, 51009, Tartu, Estonia.
Vasar E; Department of Psychiatry, Institute of Clinical Medicine, University of Tartu, 31 Raja Street, 50417, Tartu, Estonia. Liina.Haring@kliinikum.ee.
Zilmer M; Psychiatry Clinic of Tartu University Hospital, 31 Raja Street, 50417, Tartu, Estonia. Liina.Haring@kliinikum.ee.

Sci Rep ; 10(1): 13983, 2020 08 19.

Article em En | MEDLINE | ID: mdl-32814830

Assuntos

Aminoácidos/sangue; Antipsicóticos/uso terapêutico; Aminas Biogênicas/sangue; Metabolômica/métodos; Esquizofrenia/tratamento farmacológico; Adulto; Asparagina/sangue; Ácido Aspártico/sangue; Cromatografia Líquida/métodos; Diagnóstico Precoce; Feminino; Ácido Glutâmico/sangue; Glutamina/sangue; Humanos; Masculino; Metaboloma; Prolina/sangue; Esquizofrenia/sangue; Esquizofrenia/diagnóstico; Espectrometria de Massas em Tandem/métodos; Taurina/sangue; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Antipsicóticos / Aminas Biogênicas / Metabolômica / Aminoácidos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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