Differential effects of inflammation models on rat T-kininogen and rat angiotensinogen.
Biochem Pharmacol
; 37(6): 1099-102, 1988 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-3281677
ABSTRACT
The effect of different experimental models of inflammation on plasma concentrations of T-kininogen and angiotensinogen was examined in the rat. T-kininogen, a major phase protein which inhibits cysteine proteinase is increased in all cases of induced inflammation administration of lipopolysaccharide and turpentine, bilateral nephrectomy or sham-operation and intraperitoneal injection of peanut oil. Angiotensinogen, the renin-substrate, is increased by lipopolysaccharide but is decreased by turpentine. Sham-operation or peanut oil injection have no effect on angiotensinogen whereas, bilateral nephrectomy and dexamethasone increase its concentration. Therefore, angiotensinogen is regulated differently than T-kininogen during inflammation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Angiotensinogênio
/
Cininogênios
/
Inflamação
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article