Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, <i>N</i>-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death.

Hong, Dae Ki; Kho, A Ra; Lee, Song Hee; Jeong, Jeong Hyun; Kang, Beom Seok; Kang, Dong Hyeon; Park, Min Kyu; Park, Kyoung-Ha; Lim, Man-Sup; Choi, Bo Young; Suh, Sang Won

Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death.

Hong, Dae Ki; Kho, A Ra; Lee, Song Hee; Jeong, Jeong Hyun; Kang, Beom Seok; Kang, Dong Hyeon; Park, Min Kyu; Park, Kyoung-Ha; Lim, Man-Sup; Choi, Bo Young; Suh, Sang Won.

Afiliação

Hong DK; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Kho AR; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Lee SH; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Jeong JH; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Kang BS; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Kang DH; Department of Medical Science, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Park MK; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Park KH; Division of Cardiovascular Diseases, Hallym University Medical Center, Anyang 14068, Korea.
Lim MS; Department of Medical Education, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Choi BY; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.
Suh SW; Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, Korea.

Int J Mol Sci ; 21(17)2020 Aug 21.

Article em En | MEDLINE | ID: mdl-32825703

Assuntos

Acetilcisteína/farmacologia; Antioxidantes/farmacologia; Isquemia Encefálica/tratamento farmacológico; Neurônios/efeitos dos fármacos; Canais de Cátion TRPM/metabolismo; Animais; Isquemia Encefálica/metabolismo; Isquemia Encefálica/patologia; Glutationa/metabolismo; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Hipocampo/patologia; Peroxidação de Lipídeos/efeitos dos fármacos; Neuroglia/efeitos dos fármacos; Neuroglia/metabolismo; Neuroglia/patologia; Neurônios/metabolismo; Neurônios/patologia; Ratos; Canais de Cátion TRPM/antagonistas & inibidores; Zinco/metabolismo

Palavras-chave

N-acetyl-l-cysteine; global cerebral ischemia; neurodegeneration; transient receptor potential melastatin 2; zinc

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetilcisteína / Isquemia Encefálica / Canais de Cátion TRPM / Neurônios / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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