Innate immune response in neuronopathic forms of Gaucher disease confers resistance against viral-induced encephalitis.
Acta Neuropathol Commun
; 8(1): 144, 2020 08 24.
Article
em En
| MEDLINE
| ID: mdl-32831144
ABSTRACT
Both monogenic diseases and viral infections can manifest in a broad spectrum of clinical phenotypes that range from asymptomatic to lethal, suggesting that other factors modulate disease severity. Here, we examine the interplay between the genetic neuronopathic Gaucher's disease (nGD), and neuroinvasive Sindbis virus (SVNI) infection. Infection of nGD mice with SVNI had no influence on nGD severity. However, nGD mice were more resistant to SVNI infection. Significantly different inflammatory responses were seen in nGD brains when compared with SVNI brains the inflammatory response in the nGD brains consisted of reactive astrocytes and microglia with no infiltrating macrophages, but the inflammatory response in the brains of SVNI-infected mice was characterized by infiltration of macrophages and altered activation of microglia and astrocytes. We suggest that the innate immune response activated in nGD confers resistance against viral infection of the CNS.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalite Viral
/
Resistência à Doença
/
Doença de Gaucher
/
Imunidade Inata
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article