ß-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer.

Song, Ping; Feng, Lifeng; Li, Jiaqiu; Dai, Dongjun; Zhu, Liyuan; Wang, Chaoqun; Li, Jingyi; Li, Ling; Zhou, Qiyin; Shi, Rongkai; Wang, Xian; Jin, Hongchuan

Song, Ping; Feng, Lifeng; Li, Jiaqiu; Dai, Dongjun; Zhu, Liyuan; Wang, Chaoqun; Li, Jingyi; Li, Ling; Zhou, Qiyin; Shi, Rongkai; Wang, Xian; Jin, Hongchuan.

Afiliação

Song P; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Feng L; Labortary of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li J; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Dai D; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhu L; Labortary of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Wang C; Department of pathology, People's Hospital of Dongyang, Zhejiang, China.
Li J; Labortary of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Li L; Labortary of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhou Q; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Shi R; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Wang X; Department of Medical Oncology, Cancer Institute of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. wangx118@zju.edu.cn.
Jin H; Labortary of Cancer Biology, Key Lab of Biotherapy in Zhejiang, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. jinhc@zju.edu.cn.

Mol Cancer ; 19(1): 129, 2020 08 24.

Article em En | MEDLINE | ID: mdl-32838807

Assuntos

Adenosina/análogos & derivados; Neoplasias Colorretais/genética; Regulação Neoplásica da Expressão Gênica; Fatores de Transcrição de Choque Térmico/genética; MicroRNAs/genética; RNA Mensageiro/genética; beta Catenina/metabolismo; Adenosina/metabolismo; Animais; Apoptose/genética; Linhagem Celular Tumoral; Neoplasias Colorretais/metabolismo; Modelos Animais de Doenças; Humanos; Metilação; Camundongos; Modelos Biológicos; Biossíntese de Proteínas; Interferência de RNA; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Colorectal cancer; HSF1; Translation; m6A RNA modification; miR455-3p; ß-Catenin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Neoplasias Colorretais / Regulação Neoplásica da Expressão Gênica / Adenosina / MicroRNAs / Beta Catenina / Fatores de Transcrição de Choque Térmico Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google