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Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
Li, Xihao; Li, Zilin; Zhou, Hufeng; Gaynor, Sheila M; Liu, Yaowu; Chen, Han; Sun, Ryan; Dey, Rounak; Arnett, Donna K; Aslibekyan, Stella; Ballantyne, Christie M; Bielak, Lawrence F; Blangero, John; Boerwinkle, Eric; Bowden, Donald W; Broome, Jai G; Conomos, Matthew P; Correa, Adolfo; Cupples, L Adrienne; Curran, Joanne E; Freedman, Barry I; Guo, Xiuqing; Hindy, George; Irvin, Marguerite R; Kardia, Sharon L R; Kathiresan, Sekar; Khan, Alyna T; Kooperberg, Charles L; Laurie, Cathy C; Liu, X Shirley; Mahaney, Michael C; Manichaikul, Ani W; Martin, Lisa W; Mathias, Rasika A; McGarvey, Stephen T; Mitchell, Braxton D; Montasser, May E; Moore, Jill E; Morrison, Alanna C; O'Connell, Jeffrey R; Palmer, Nicholette D; Pampana, Akhil; Peralta, Juan M; Peyser, Patricia A; Psaty, Bruce M; Redline, Susan; Rice, Kenneth M; Rich, Stephen S; Smith, Jennifer A; Tiwari, Hemant K.
Afiliação
  • Li X; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Li Z; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Zhou H; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Gaynor SM; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Liu Y; School of Statistics, Southwestern University of Finance and Economics, Chengdu, China.
  • Chen H; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Sun R; Center for Precision Health, School of Public Health and School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Dey R; Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Arnett DK; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Aslibekyan S; College of Public Health, University of Kentucky, Lexington, KY, USA.
  • Ballantyne CM; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Bielak LF; Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
  • Blangero J; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Boerwinkle E; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA.
  • Bowden DW; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Broome JG; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
  • Conomos MP; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Correa A; Division of Medical Genetics, University of Washington, Seattle, WA, USA.
  • Cupples LA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Curran JE; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  • Freedman BI; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  • Guo X; Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA.
  • Hindy G; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA.
  • Irvin MR; Department of Internal Medicine, Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Kardia SLR; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
  • Kathiresan S; Department of Population Medicine, Qatar University College of Medicine, QU Health, Doha, Qatar.
  • Khan AT; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Kooperberg CL; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Laurie CC; Verve Therapeutics, Cambridge, MA, USA.
  • Liu XS; Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.
  • Mahaney MC; Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • Manichaikul AW; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Martin LW; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Mathias RA; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • McGarvey ST; Department of Data Sciences, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Mitchell BD; Department of Statistics, Harvard University, Cambridge, MA, USA.
  • Montasser ME; Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA.
  • Moore JE; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
  • Morrison AC; Division of Cardiology, George Washington School of Medicine and Health Sciences, Washington, DC, USA.
  • O'Connell JR; GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Palmer ND; Department of Epidemiology, International Health Institute, Department of Anthropology, Brown University, Providence, RI, USA.
  • Pampana A; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Peralta JM; Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA.
  • Peyser PA; Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Psaty BM; Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, USA.
  • Redline S; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Rice KM; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Rich SS; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
  • Smith JA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Tiwari HK; Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
Nat Genet ; 52(9): 969-983, 2020 09.
Article em En | MEDLINE | ID: mdl-32839606
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Genoma / Predisposição Genética para Doença Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Variação Genética / Genoma / Predisposição Genética para Doença Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article