Postoperative expressive aphasia associated with intravenous midazolam administration: a 5-year retrospective case-control study.
J Int Med Res
; 48(8): 300060520948751, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32851907
ABSTRACT
OBJECTIVES:
This study aimed to investigate the epidemiology of intravenous midazolam-induced postoperative expressive aphasia (EA).METHODS:
The incidence rate, risk ratio, and contributing factors to intravenous midazolam-induced postoperative EA were analyzed retrospectively in 6756 orthopedic patients. A telephone interview was conducted with patients with EA after surgery.RESULTS:
Patients were allocated to either the midazolam group (n = 6178) or no-midazolam group (n = 578). Twelve patients developed EA in the midazolam group, with an incidence of 0.19%, and no patient developed EA in the no-midazolam group. The mean age of EA patients was 70 years, and 92% were women. Among them, 75% received general anesthesia, and the mean dose of midazolam was 1.8 mg. EA was reversed in nine of 12 (75%) patients within 4 minutes of flumazenil administration, and >60 minutes were required to reverse EA in the other three patients (25%).CONCLUSION:
Intravenous midazolam administration for preoperative sedation caused transient EA in 0.19% of patients, especially elderly women who received general anesthesia, and EA could be reversed by flumazenil.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Afasia de Broca
/
Midazolam
Tipo de estudo:
Observational_studies
Limite:
Aged
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Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article