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Antibacterial activity of fluoxetine-loaded starch nanocapsules.
Dos Santos, Sarah B F; Pereira, Stéfano A; Rodrigues, Francisco A M; da Silva, Aiêrta C C; de Almeida, Raimundo R; Sousa, Alexandre C C; Fechine, Lillian M U D; Denardin, Juliano C; Araneda, Fabián; Sá, Lívia G A V; da Silva, Cecília R; Nobre Júnior, Hélio V; Ricardo, Nágila M P S.
Afiliação
  • Dos Santos SBF; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • Pereira SA; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • Rodrigues FAM; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • da Silva ACC; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • de Almeida RR; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • Sousa ACC; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil; Federal Institute of Education, Science and Technology of Ceará, Campus Quixadá, Quixadá, CE Zip Cod
  • Fechine LMUD; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
  • Denardin JC; Department of Physics and CEDENNA, University of Santiago, Zip Code 9170124 Santiago, Chile.
  • Araneda F; Department of Physics and CEDENNA, University of Santiago, Zip Code 9170124 Santiago, Chile.
  • Sá LGAV; Laboratory of Bioprospection in Antimicrobial Molecules, Department of Pharmacy, Federal University of Ceará, Zip Code 60430-275 Fortaleza, CE, Brazil.
  • da Silva CR; Laboratory of Bioprospection in Antimicrobial Molecules, Department of Pharmacy, Federal University of Ceará, Zip Code 60430-275 Fortaleza, CE, Brazil.
  • Nobre Júnior HV; Laboratory of Bioprospection in Antimicrobial Molecules, Department of Pharmacy, Federal University of Ceará, Zip Code 60430-275 Fortaleza, CE, Brazil.
  • Ricardo NMPS; Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil. Electronic address: naricard@ufc.br.
Int J Biol Macromol ; 164: 2813-2817, 2020 Dec 01.
Article em En | MEDLINE | ID: mdl-32853612
ABSTRACT
This work proposes the development of a starch-based drug carrier for fluoxetine (FLX) delivery and evaluate the improvement of the drug antibacterial activity. The starch nanocapsules were prepared via interfacial polyaddition reaction presenting a core-shell morphology, based on polyurethane linkage, with a particle size in the range 250-300 nm. Furthermore, FLX-loaded nanocapsules were evaluated regarding antibacterial potential against Staphylococcus aureus (ATCC® 6538P ™) and its clinical strains of methicillin-resistant. As expected, the FLX-loaded presented lower minimum inhibitory concentration (MIC) values, in the range of 190-95 µg mL-1, against all isolated microorganisms in comparison to FLX, 255 µg mL-1. According to results, the FLX-loaded starch nanocapsules have successfully improved drug antibacterial activity, generating promising perspectives on the field of the hydrophilic drug delivery systems.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amido / Fluoxetina / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Amido / Fluoxetina / Antibacterianos Idioma: En Ano de publicação: 2020 Tipo de documento: Article