Losing Regulation of the Extracellular Matrix is Strongly Predictive of Unfavorable Prognostic Outcome after Acute Myocardial Infarction.

Sung, Pei-Hsun; Lin, Kun-Chen; Chai, Han-Tan; Chiang, John Y; Shao, Pei-Lin; Luo, Chi-Wen; Yip, Hon-Kan

Sung, Pei-Hsun; Lin, Kun-Chen; Chai, Han-Tan; Chiang, John Y; Shao, Pei-Lin; Luo, Chi-Wen; Yip, Hon-Kan.

Afiliação

Sung PH; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Lin KC; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Chai HT; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
Chiang JY; Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Shao PL; Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan.
Luo CW; Department of Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung 804201, Taiwan.
Yip HK; Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.

Int J Mol Sci ; 21(17)2020 Aug 27.

Article em En | MEDLINE | ID: mdl-32867392

Assuntos

Biomarcadores/metabolismo; Matriz Extracelular/metabolismo; Metaloproteinase 9 da Matriz/genética; Infarto do Miocárdio/fisiopatologia; Antígeno Polipeptídico Tecidual/genética; Animais; Modelos Animais de Doenças; Regulação da Expressão Gênica; Ventrículos do Coração/fisiopatologia; Masculino; Camundongos; Camundongos Knockout; Mortalidade; Infarto do Miocárdio/genética; Infarto do Miocárdio/metabolismo; Infarto do Miocárdio/mortalidade; Tamanho do Órgão; Prognóstico; Volume Sistólico

Palavras-chave

acute myocardial infarction; double knock-out of MMP9 and tPA; poor prognostic outcome

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Antígeno Polipeptídico Tecidual / Metaloproteinase 9 da Matriz / Matriz Extracelular / Infarto do Miocárdio Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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