Gastropathy associated with lanthanum phosphate deposition that was endoscopically tracked for 3 years. A case report.
BMC Gastroenterol
; 20(1): 292, 2020 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-32867713
ABSTRACT
BACKGROUND:
With the recent increased use of lanthanum carbonate, several cases of lanthanum phosphate deposition to gastric mucosa in dialysis patients have been reported. However, the endoscopic appearance of the early-stage lesion and the over-time alterations of endoscopic findings due to the progression of lanthanum phosphate deposition remain unclear. CASE PRESENTATION An 80-year-old man receiving dialysis and taking lanthanum carbonate as a phosphate binder over a 4-year period underwent upper gastrointestinal endoscopy four times beginning 1 year after initiation of treatment. The first endoscopic examination (after 1 year of exposure to lanthanum carbonate) revealed rough mucosa with a few areas of white granular mucosa. Over the 3 years of endoscopic follow-up, the white granular mucosa spread and multiple erosions appeared. Histopathological findings of biopsy specimens from an erosion showed extensive infiltration by histiocytes containing deposits. Scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX) revealed that the presence of the deposits containing phosphorus and lanthanum in the gastric mucosa. On the basis of these results, the patient was diagnosed with gastropathy associated with lanthanum phosphate deposition.CONCLUSIONS:
Over a 3-year period, endoscopic findings associated with lanthanum deposition gradually changed and expanded from the early stage.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gastropatias
/
Falência Renal Crônica
Tipo de estudo:
Risk_factors_studies
Limite:
Aged80
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article