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DL0410 ameliorates cognitive disorder in SAMP8 mice by promoting mitochondrial dynamics and the NMDAR-CREB-BDNF pathway.
Lian, Wen-Wen; Zhou, Wei; Zhang, Bao-Yue; Jia, Hao; Xu, Lv-Jie; Liu, Ai-Lin; Du, Guan-Hua.
Afiliação
  • Lian WW; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Zhou W; Department of Pharmacy, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Zhang BY; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Jia H; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Xu LJ; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Liu AL; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • Du GH; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. liuailin@imm.ac.cn.
Acta Pharmacol Sin ; 42(7): 1055-1068, 2021 Jul.
Article em En | MEDLINE | ID: mdl-32868905
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Compostos de Bifenilo / Transdução de Sinais / Nootrópicos / Doença de Alzheimer / Dinâmica Mitocondrial / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Compostos de Bifenilo / Transdução de Sinais / Nootrópicos / Doença de Alzheimer / Dinâmica Mitocondrial / Mitocôndrias Limite: Animals Idioma: En Ano de publicação: 2021 Tipo de documento: Article