Evaluation of covalent binding of flutamide and its risk assessment using <sup>19</sup>F-NMR.

Kakutani, Nobuyuki; Iwai, Takahiro; Ohno, Yasushi; Kobayashi, Satoru; Nomura, Yukihiro

Evaluation of covalent binding of flutamide and its risk assessment using ¹⁹F-NMR.

Kakutani, Nobuyuki; Iwai, Takahiro; Ohno, Yasushi; Kobayashi, Satoru; Nomura, Yukihiro.

Afiliação

Kakutani N; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan Tobacco Inc, Takatsuki, Japan.
Iwai T; Product Development Laboratories, Japan Tobacco Inc, Takatsuki, Japan.
Ohno Y; Product Development Laboratories, Japan Tobacco Inc, Takatsuki, Japan.
Kobayashi S; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan Tobacco Inc, Takatsuki, Japan.
Nomura Y; Drug Metabolism and Pharmacokinetics Research Laboratories, Japan Tobacco Inc, Takatsuki, Japan.

Xenobiotica ; 51(1): 88-94, 2021 Jan.

Article em En | MEDLINE | ID: mdl-32876521

Assuntos

Antineoplásicos Hormonais/toxicidade; Flutamida/toxicidade; Antineoplásicos Hormonais/metabolismo; Doença Hepática Induzida por Substâncias e Drogas; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos; Flutamida/metabolismo; Humanos; Espectroscopia de Ressonância Magnética; Microssomos Hepáticos/metabolismo

Palavras-chave

F nuclear magnetic resonance; Reactive metabolites; covalent binding; hepatotoxicity; quantitative nuclear magnetic resonance; reactive metabolite burden

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antineoplásicos Hormonais / Flutamida Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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