Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase Î¶.

Meers, Chance; Keskin, Havva; Banyai, Gabor; Mazina, Olga; Yang, Taehwan; Gombolay, Alli L; Mukherjee, Kuntal; Kaparos, Efiyenia I; Newnam, Gary; Mazin, Alexander; Storici, Francesca

Meers, Chance; Keskin, Havva; Banyai, Gabor; Mazina, Olga; Yang, Taehwan; Gombolay, Alli L; Mukherjee, Kuntal; Kaparos, Efiyenia I; Newnam, Gary; Mazin, Alexander; Storici, Francesca.

Afiliação

Meers C; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Keskin H; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Banyai G; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mazina O; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Yang T; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Gombolay AL; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mukherjee K; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Kaparos EI; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Newnam G; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Mazin A; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Storici F; School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address: storici@gatech.edu.

Mol Cell ; 79(6): 1037-1050.e5, 2020 09 17.

Article em En | MEDLINE | ID: mdl-32882183

Assuntos

DNA/genética; RNA/genética; Saccharomyces cerevisiae/genética; Adolescente; Adulto; DNA/ultraestrutura; Quebras de DNA de Cadeia Dupla; Reparo do DNA/genética; Replicação do DNA/genética; DNA Complementar/genética; DNA Polimerase Dirigida por DNA/genética; DNA Polimerase Dirigida por DNA/ultraestrutura; Instabilidade Genômica/genética; Humanos; Pessoa de Meia-Idade; RNA/ultraestrutura; Proteína Rad52 de Recombinação e Reparo de DNA/genética; Adulto Jovem

Palavras-chave

DNA polymerase Î¶; DNA repair; REV3; RNA recombination; RNA-mediated; RNA-templated; cDNA-mediated; homologous recombination; reverse transcriptase; translesion polymerase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Saccharomyces cerevisiae / DNA / RNA Limite: Adolescent / Adult / Humans / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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