Lung-targeting lentiviral vector for passive immunisation against influenza.

Tan, Tiong Kit; Gamlen, Toby P E; Rijal, Pramila; Townsend, Alain R; Gill, Deborah R; Hyde, Stephen C

Tan, Tiong Kit; Gamlen, Toby P E; Rijal, Pramila; Townsend, Alain R; Gill, Deborah R; Hyde, Stephen C.

Afiliação

Tan TK; Radcliffe Department of Medicine, Gene Medicine Research Group, Nuffield Division of Clinical Laboratory Science, Oxford, UK.
Gamlen TPE; Radcliffe Department of Medicine, Gene Medicine Research Group, Nuffield Division of Clinical Laboratory Science, Oxford, UK.
Rijal P; Radcliffe Department of Medicine, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Oxford, UK.
Townsend AR; Radcliffe Department of Medicine, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Oxford, UK.
Gill DR; Gene Medicine Research Group, Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, Oxford University, Oxford, UK.
Hyde SC; UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK.

Thorax ; 75(12): 1112-1115, 2020 12.

Article em En | MEDLINE | ID: mdl-32883885

ABSTRACT

ABSTRACT

When recombinant simian immunodeficiency virus (SIV) is pseudotyped with the F and HN glycoproteins from murine respiratory Sendai virus (rSIV.F/HN), it provides efficient lung cell targeting and lifelong transgene expression in the murine airways. We have shown that a single dose of rSIV.F/HN can direct stable expression of neutralising antibody against influenza in the murine airways and systemic circulation, and protects mice against two different influenza strains in lethal challenge experiments. These data suggest that rSIV.F/HN could be used as a vector for passive immunisation against influenza and other respiratory pathogens.

Assuntos

Anticorpos Neutralizantes/genética; Vetores Genéticos/imunologia; Vírus da Influenza A Subtipo H1N1/imunologia; Pulmão/imunologia; Infecções por Orthomyxoviridae/prevenção & controle; Vírus da Imunodeficiência Símia/genética; Animais; Anticorpos Neutralizantes/imunologia; Expressão Gênica; Vetores Genéticos/administração & dosagem; Glicoproteínas de Hemaglutininação de Vírus da Influenza; Imunização Passiva; Imunoglobulina G; Camundongos; Vírus Sendai/genética; Transgenes; Redução de Peso

Palavras-chave

infection control; respiratory infection; viral infection

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus da Imunodeficiência Símia / Infecções por Orthomyxoviridae / Vírus da Influenza A Subtipo H1N1 / Anticorpos Neutralizantes / Vetores Genéticos / Pulmão Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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