Activating the Antibacterial Effect of 4,6-Diamino-2-pyrimidinethiol-Modified Gold Nanoparticles by Reducing their Sizes.
Angew Chem Int Ed Engl
; 59(52): 23471-23475, 2020 12 21.
Article
em En
| MEDLINE
| ID: mdl-32886827
ABSTRACT
Adequately decorated gold nanoparticles (GNPs) have excellent antibiotic activities against multidrug-resistant (MDR) bacteria. Nanoparticles exhibiting Gram selective antibacterial actions are beneficial to precise therapy. Here, we present a strategy to tune the antibacterial spectrum of a small molecule (4,6-diamino-2-pyrimidinethiol, DAPT)-modified GNPs (DAPT-GNPs, DGNPs) by adjusting their sizes. Compared to large (ca. 14â
nm diameter) DGNPs (lDGNPs) and medium-sized (3-4â
nm diameter) DGNPs (mDGNPs), which have no antibacterial effect or only target Gram-negative (G-) bacteria, ultrasmall DGNPs (uDGNPs, <2â
nm) have a broad antibacterial spectrum, especially showing an over 60-fold increase in antibacterial efficacy against Gram-positive (G+) bacteria. Moreover, the uDGNPs-functionalized scaffolds (agarose gel) can serve as general wound dressings for healing burnt infections. Our strategy is insightful for exploring properties of the nanomaterials and their applications.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Nanopartículas Metálicas
/
Ouro
/
Antibacterianos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article