A proton-coupled folate transporter mutation causing hereditary folate malabsorption locks the protein in an inward-open conformation.

Zhan, He-Qin; Najmi, Mitra; Lin, Kai; Aluri, Srinivas; Fiser, Andras; Goldman, I David; Zhao, Rongbao

Zhan, He-Qin; Najmi, Mitra; Lin, Kai; Aluri, Srinivas; Fiser, Andras; Goldman, I David; Zhao, Rongbao.

Afiliação

Zhan HQ; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Pathology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
Najmi M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.
Lin K; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; Air Force Medical Center, People's Liberation Army, Beijing, China.
Aluri S; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA.
Fiser A; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA.
Goldman ID; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: i.david.goldman@einsteinmed.org.
Zhao R; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, USA; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.

J Biol Chem ; 295(46): 15650-15661, 2020 11 13.

Article em En | MEDLINE | ID: mdl-32893190

Assuntos

Transportador de Folato Acoplado a Próton/metabolismo; Sequência de Aminoácidos; Animais; Transporte Biológico; Cisteína/química; Cisteína/metabolismo; Deficiência de Ácido Fólico/patologia; Células HeLa; Humanos; Cinética; Síndromes de Malabsorção/patologia; Metotrexato/metabolismo; Mutagênese Sítio-Dirigida; Estrutura Terciária de Proteína; Transportador de Folato Acoplado a Próton/química; Transportador de Folato Acoplado a Próton/genética

Palavras-chave

PCFT; SLC46A1; facilitative transporters; folate; hereditary folate malabsorption (HFM); homology modeling; methotrexate; mutant; mutually compensatory mutations; proton transport; proton-coupled folate transporter; reduced folate carrier; suppressor mutations; transporter

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador de Folato Acoplado a Próton Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google