Analysis of biomarkers and metabolic pathways in patients with unstable angina based on ultrahighperformance liquid chromatographyquadrupole timeofflight mass spectrometry.
Mol Med Rep
; 22(5): 3862-3872, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32901869
ABSTRACT
Unstable angina (UA) is a coronary disease with a high mortality and morbidity worldwide. The present study aimed to use noninvasive techniques to identify urine biomarkers in patients with UA, so as to provide more information for the early diagnosis and treatment of the disease. Based on metabolomics, urine samples from 28 patients with UA and 28 healthy controls (HCs) were analyzed using ultrahighperformance liquid chromatographyquadrupole timeofflight mass spectrometry (UPLCQTOF/MS). A total of 16 significant biomarkers that could distinguish between patients with UA and HCs, including Dglucuronic acid, creatinine, succinic acid and Nacetylneuraminic acid, were identified. The major metabolic pathways associated with UA were subsequently analyzed by nontargeted metabolomics. The results demonstrated that amino acid and energy metabolism, fatty acid metabolism, purine metabolism and steroid hormone biosynthetic metabolism may serve important roles in UA. The results of the current study may provide a theoretical basis for the early diagnosis of UA and novel treatment strategies for clinicians. The trial was registered with the Chinese Clinical Trial Registration Center (registration no. ChiCTRROC17013957) at Tianjin University of Traditional Chinese Medicine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores
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Ácido Succínico
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Creatinina
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Ácido Glucurônico
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Metabolômica
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Angina Instável
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article