Systematical NMR analysis of swainsonine, a mycotoxin from endophytic fungus Alternaria oxytropis.
Magn Reson Chem
; 59(1): 16-22, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32910519
ABSTRACT
Swainsonine (SW, 1), a unique indolizine with poly-hydroxyl groups, was re-isolated from the plant endophytic fungus Alternaria oxytropis. The structure (including planar structure and relative configuration) was systematically elucidated by NMR spectra (including 1 H, 13 C, 1 H-1 H COSY, HMQC, HMBC, and NOESY spectra in DMSO-d6 and in CD3 OD); 1 H NMR spectra of the modified Mosher's products were first used to determine the absolute configuration of SW. More importantly, the complex coupled features of H-7α, H-7ß, and H-6α in the 1 H NMR spectrum of (1) were analyzed in details, which will provide aids for the planar and relative configuration determination of analogs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Swainsonina
/
Micotoxinas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article