[Mutational analysis of ATP7B gene of hepatolenticular degeneration in Xinjiang region].
Zhonghua Gan Zang Bing Za Zhi
; 28(8): 699-702, 2020 Aug 20.
Article
em Zh
| MEDLINE
| ID: mdl-32911910
ABSTRACT
Objective:
To understand the mutational characteristics of ATP7B gene of hepatolenticular degeneration in Xinjiang region.Methods:
24 cases were diagnosed as hepatolenticular degeneration and the exon of ATP7B gene was detected in some of their siblings and parents.Results:
A total of 45 ATP7B gene mutations (93.75%) were detected in 24 cases, of which 14 cases were homozygous mutations or compound heterozygous mutations, six cases were heterozygous mutations and four cases were no mutations. A total of 24 gene mutations and 14 SNPS were detected, including 8 new mutations c.251C > A, c.121A > c, c.2945C > A, c.2194C > T, c.2947T > c, c.3626T > A, c.3662_3664del, c.3557G > T. The most common mutations were c.2621C > T (p.A874V) [16.7% (4/24)] and c.2333G > T (p.R778L) [12.5% ââ(3/24)]. A total of 4 cases were diagnosed as pre-symptomatic.Conclusion:
In this study, the most common mutation in the ATP7B gene is A874V. The most common genetic mutations in Han and Uyghur patients were different. The most common mutation in Han and Uyghur patients is R778L and A874V. Exon 11 is the gene mutations hot spot for patients with hepatolenticular degeneration in Xinjiang region, and is one of the priority exons to be detected when screening patients with suspected hepatolenticular degeneration.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte de Cátions
/
ATPases Transportadoras de Cobre
/
Degeneração Hepatolenticular
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article