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MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.
Munkhbaatar, Enkhtsetseg; Dietzen, Michelle; Agrawal, Deepti; Anton, Martina; Jesinghaus, Moritz; Boxberg, Melanie; Pfarr, Nicole; Bidola, Pidassa; Uhrig, Sebastian; Höckendorf, Ulrike; Meinhardt, Anna-Lena; Wahida, Adam; Heid, Irina; Braren, Rickmer; Mishra, Ritu; Warth, Arne; Muley, Thomas; Poh, Patrina S P; Wang, Xin; Fröhling, Stefan; Steiger, Katja; Slotta-Huspenina, Julia; van Griensven, Martijn; Pfeiffer, Franz; Lange, Sebastian; Rad, Roland; Spella, Magda; Stathopoulos, Georgios T; Ruland, Jürgen; Bassermann, Florian; Weichert, Wilko; Strasser, Andreas; Branca, Caterina; Heikenwalder, Mathias; Swanton, Charles; McGranahan, Nicholas; Jost, Philipp J.
Afiliação
  • Munkhbaatar E; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Dietzen M; Cancer Research UK Lung Cancer Center of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK.
  • Agrawal D; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
  • Anton M; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK.
  • Jesinghaus M; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Boxberg M; Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Pfarr N; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Bidola P; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Uhrig S; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Höckendorf U; Chair of Biomedical Physics, Department of Physics & Munich School of Bioengineering, Technical University of Munich, Garching, Germany.
  • Meinhardt AL; Division of Applied Bioinformatics, German Cancer Research Center, Heidelberg, Germany.
  • Wahida A; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
  • Heid I; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Braren R; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Mishra R; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Warth A; Department of diagnostic and interventional radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Muley T; Department of diagnostic and interventional radiology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Poh PSP; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.
  • Wang X; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
  • Fröhling S; Institute of Pathology, Cytopathology and Molecular Pathology UEGP MVZ, Giessen, Wetzlar, Limburg, Germany.
  • Steiger K; Translational Research Unit, Thoraxklinik at Heidelberg University, Heidelberg, Germany.
  • Slotta-Huspenina J; Translational Lung Research Centre (TLRC) Heidelberg, member of the German Centre for lung Research (DZL), Heidelberg, Germany.
  • van Griensven M; Experimental Trauma Surgery, Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Pfeiffer F; Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Lange S; Department of Medicine III, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Rad R; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Spella M; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Stathopoulos GT; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Ruland J; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Bassermann F; Institute of Pathology, Technical University of Munich, Munich, Germany.
  • Weichert W; Gewebebank des Klinikums rechts der Isar und der Technischen Universität München Am Institut für Pathologie der TU München, München, Germany.
  • Strasser A; Department cBITE, MERLN Institute, Maastricht University, Maastricht, The Netherlands.
  • Branca C; Chair of Biomedical Physics, Department of Physics & Munich School of Bioengineering, Technical University of Munich, Garching, Germany.
  • Heikenwalder M; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.
  • Swanton C; Institute of Molecular Oncology and Functional Genomics, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • McGranahan N; Department of Medicine II, Klinikum rechts der Isar, TUM School of Medicine, Technical University of Munich, Munich, Germany.
  • Jost PJ; Center for Translational Cancer Research (TranslaTUM), Technical University of Munich, Munich, Germany.
Nat Commun ; 11(1): 4527, 2020 09 10.
Article em En | MEDLINE | ID: mdl-32913197
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Proteína de Sequência 1 de Leucemia de Células Mieloides / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Proteína de Sequência 1 de Leucemia de Células Mieloides / Neoplasias Pulmonares / Antineoplásicos Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article