Progressive plasmacytoid variant bladder cancer with retroperitoneal dissemination: An autopsy case report.
IJU Case Rep
; 3(5): 166-169, 2020 Sep.
Article
em En
| MEDLINE
| ID: mdl-32914061
ABSTRACT
INTRODUCTION:
Plasmacytoid urothelial carcinoma is a rare and aggressive variant of bladder cancer. CASE PRESENTATION A 75-year-old woman presented with plasmacytoid urothelial carcinoma with retroperitoneal dissemination was treated with chemotherapy. After an unsuccessful first-line chemotherapy with gemcitabine and cisplatin, we assessed circulating tumor cells; one such cell was found to be positive for programmed death-ligand 1. The patient received second-line chemotherapy with pembrolizumab. However, the tumor extended to the retroperitoneal organs, and the patient eventually died. Autopsy revealed a widespread diffuse scirrhous infiltration of the carcinoma into the retroperitoneum. However, distant metastasis was not observed.CONCLUSION:
The evaluation of circulating tumor cells and autopsy revealed a disease state of progressive plasmacytoid urothelial carcinoma treated with pembrolizumab.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article