Four-octyl itaconate activates Nrf2 cascade to protect osteoblasts from hydrogen peroxide-induced oxidative injury.

Zheng, Yuehuan; Chen, Zhe; She, Chang; Lin, Yazhou; Hong, Yuan; Shi, Liqiang; Zhang, Yingzi; Cao, Peng; Xu, Xiangyang

Zheng, Yuehuan; Chen, Zhe; She, Chang; Lin, Yazhou; Hong, Yuan; Shi, Liqiang; Zhang, Yingzi; Cao, Peng; Xu, Xiangyang.

Afiliação

Zheng Y; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen Z; Department of Orthopedics, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
She C; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin Y; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Hong Y; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shi L; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang Y; Department of Orthopedics, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cao P; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu X; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China. zhanggyz@suda.edu.cn.

Cell Death Dis ; 11(9): 772, 2020 09 17.

Article em En | MEDLINE | ID: mdl-32943614

Assuntos

Peróxido de Hidrogênio/metabolismo; Fator 2 Relacionado a NF-E2/metabolismo; Osteoblastos/efeitos dos fármacos; Estresse Oxidativo; Succinatos/farmacologia; Transporte Ativo do Núcleo Celular; Fosfatase Alcalina/metabolismo; Animais; Antioxidantes/metabolismo; Apoptose; Carboxiliases/metabolismo; Diferenciação Celular; Sobrevivência Celular; Citosol/metabolismo; Perfilação da Expressão Gênica; Regulação Neoplásica da Expressão Gênica; Inativação Gênica; Humanos; Hidroliases/metabolismo; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Camundongos; Necrose; Espécies Reativas de Oxigênio; Transdução de Sinais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoblastos / Succinatos / Estresse Oxidativo / Fator 2 Relacionado a NF-E2 / Peróxido de Hidrogênio Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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