Development of a core outcome set for use in routine orthodontic clinical trials.
Am J Orthod Dentofacial Orthop
; 158(5): 650-660, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32950336
ABSTRACT
INTRODUCTION:
A diverse range of outcomes is used in orthodontic research with a focus on measuring outcomes important to clinicians and little consistency in outcome selection and measurement. We aimed to develop a core outcome set for use in clinical trials of orthodontic treatment not involving cleft or orthognathic patient groups.METHODS:
A list of outcomes measured in previous orthodontic research was identified through a scoping literature review. Additional outcomes of importance to patients were obtained using qualitative interviews and focus groups with adolescents aged 10-16 years. Rating of outcomes was carried out in a 2-round electronic Delphi process involving health care professionals and patients using a 9-point scale. A face-to-face meeting was subsequently held with stakeholders to discuss the results before refining the core outcome set.RESULTS:
After triangulation, a final list of 34 outcomes grouped under 10 domains was obtained for rating in the e-Delphi surveys. Fifteen outcomes were voted "in" after the second Delphi round involving 274 participants with a further outcome being included after the consensus meeting. These were subsequently refined into a final set of 7 core outcomes, including the impact of self-perceived esthetics, alignment and/or occlusion, skeletal relationship, stability, patient-related adherence, breakages, and adverse effects on teeth or teeth-supporting structures.CONCLUSIONS:
A bespoke orthodontic core outcome set encompassing both clinician- and patient-focused outcomes was developed. Incorporating this is the first step into providing a more holistic assessment of the impact of treatment while allowing for meaningful comparisons and synthesis of results from individual trials.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ortodontia
/
Projetos de Pesquisa
/
Ensaios Clínicos como Assunto
/
Estética Dentária
Tipo de estudo:
Guideline
/
Prognostic_studies
/
Qualitative_research
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article