Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.

Nie, Litong; Wang, Chao; Li, Nan; Feng, Xu; Lee, Namsoo; Su, Dan; Tang, Mengfan; Yao, Fan; Chen, Junjie

Nie, Litong; Wang, Chao; Li, Nan; Feng, Xu; Lee, Namsoo; Su, Dan; Tang, Mengfan; Yao, Fan; Chen, Junjie.

Afiliação

Nie L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Wang C; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Li N; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Feng X; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Lee N; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Su D; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Tang M; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Yao F; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Chen J; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Electronic address: jchen8@mdanderson.org.

Mol Cell Proteomics ; 19(12): 2015-2030, 2020 12.

Article em En | MEDLINE | ID: mdl-32958691

Assuntos

Proteólise; Proteoma/metabolismo; Proteômica; Ubiquitina-Proteína Ligases/metabolismo; Proteínas Fetais/metabolismo; Compostos Heterocíclicos com 3 Anéis/farmacologia; Humanos; Modelos Biológicos; Proteínas Tirosina Quinases/metabolismo; Proteólise/efeitos dos fármacos; Reprodutibilidade dos Testes; Especificidade por Substrato/efeitos dos fármacos; Regulação para Cima/efeitos dos fármacos

Palavras-chave

E3 ubiquitin ligase; RNF146; TNKS; UbiquitinasesS; cancer biology; label-free quantification; mass spectrometry; protein degradation; substrate identification; substrates; ubiquitin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Proteômica / Ubiquitina-Proteína Ligases / Proteólise Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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