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Imipenem plus Fosfomycin as Salvage Therapy for Vertebral Osteomyelitis.
Nakamura, Itaru; Yamaguchi, Tetsuo; Aoki, Kotaro; Miura, Yuri; Sato, Satoko; Fujita, Hiroaki; Watanabe, Hidehiro.
Afiliação
  • Nakamura I; Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.
  • Yamaguchi T; Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, Tokyo, Japan tetsuo.yamaguchi@med.toho-u.ac.jp.
  • Aoki K; Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, Tokyo, Japan.
  • Miura Y; Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.
  • Sato S; Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.
  • Fujita H; Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.
  • Watanabe H; Department of Infection Prevention and Control, Tokyo Medical University Hospital, Tokyo, Japan.
Antimicrob Agents Chemother ; 65(1)2020 12 16.
Article em En | MEDLINE | ID: mdl-32958715
ABSTRACT
We applied combination antibiotic therapy to treat vertebral osteomyelitis and a psoas abscess caused by glycopeptide-intermediate (MIC, 2 µg/ml) and daptomycin-nonsusceptible (>2 µg/ml) methicillin-resistant Staphylococcus aureus The Etest synergy test showed the largest synergistic effects for imipenem/cilastatin and fosfomycin. Whole-gene sequencing showed amino acid changes in SA0802, SA1193 (mprF), and SA1531 (ald). Four weeks of combination treatment using imipenem/cilastatin (1.5 g per day) and fosfomycin (4.0 g per day) resulted in clinical improvement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina / Fosfomicina Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Infecções Estafilocócicas / Staphylococcus aureus Resistente à Meticilina / Fosfomicina Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article