COVID-19 and Respiratory System Disorders: Current Knowledge, Future Clinical and Translational Research Questions.
Arterioscler Thromb Vasc Biol
; 40(11): 2586-2597, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32960072
ABSTRACT
The severe acute respiratory syndrome coronavirus-2 emerged as a serious human pathogen in late 2019, causing the disease coronavirus disease 2019 (COVID-19). The most common clinical presentation of severe COVID-19 is acute respiratory failure consistent with the acute respiratory distress syndrome. Airway, lung parenchymal, pulmonary vascular, and respiratory neuromuscular disorders all feature in COVID-19. This article reviews what is known about the effects of severe acute respiratory syndrome coronavirus-2 infection on different parts of the respiratory system, clues to understanding the underlying biology of respiratory disease, and highlights current and future translation and clinical research questions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Viral
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Respiração
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Síndrome do Desconforto Respiratório
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Insuficiência Respiratória
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Infecções por Coronavirus
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Pesquisa Translacional Biomédica
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Betacoronavirus
/
Pulmão
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article