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Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy.
Mastellos, Dimitrios C; Pires da Silva, Bruno G P; Fonseca, Benedito A L; Fonseca, Natasha P; Auxiliadora-Martins, Maria; Mastaglio, Sara; Ruggeri, Annalisa; Sironi, Marina; Radermacher, Peter; Chrysanthopoulou, Akrivi; Skendros, Panagiotis; Ritis, Konstantinos; Manfra, Ilenia; Iacobelli, Simona; Huber-Lang, Markus; Nilsson, Bo; Yancopoulou, Despina; Connolly, E Sander; Garlanda, Cecilia; Ciceri, Fabio; Risitano, Antonio M; Calado, Rodrigo T; Lambris, John D.
Afiliação
  • Mastellos DC; National Center for Scientific Research 'Demokritos', Aghia Paraskevi, Athens, Greece.
  • Pires da Silva BGP; Department of Medical Imaging, Hematology and Clinical Oncology, University of São Paulo, Ribeirão Preto, School of Medicine, Brazil.
  • Fonseca BAL; Department of Internal Medicine, University of São Paulo, Ribeirão Preto School of Medicine, Brazil.
  • Fonseca NP; Department of Medical Imaging, Hematology and Clinical Oncology, University of São Paulo, Ribeirão Preto, School of Medicine, Brazil.
  • Auxiliadora-Martins M; Intensive Care Unit, University Hospital, University of São Paulo, Ribeirão Preto School of Medicine, Brazil.
  • Mastaglio S; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ruggeri A; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Sironi M; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy.
  • Radermacher P; Sektion Anästhesiologische Pathophysiologie und Verfahrensentwicklung, University Hospital of Ulm, Ulm, Germany.
  • Chrysanthopoulou A; First Department of Internal Medicine and Laboratory of Molecular Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Skendros P; First Department of Internal Medicine and Laboratory of Molecular Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Ritis K; First Department of Internal Medicine and Laboratory of Molecular Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
  • Manfra I; AORN San Giuseppe Moscati, Hematology and Hematopoietic Stem Cell Transplantation Unit, Avellino, Italy.
  • Iacobelli S; Department of Biology, University of Rome Tor Vergata, Rome, Italy.
  • Huber-Lang M; Institute for Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, Ulm, Germany.
  • Nilsson B; Division of Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden.
  • Yancopoulou D; Amyndas Pharmaceuticals, Glyfada, Greece.
  • Connolly ES; Department of Neurological Surgery, Columbia University, New York, NY, USA.
  • Garlanda C; Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy; Humanitas University, Pieve Emanuele, Milan, Italy.
  • Ciceri F; Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; University Vita Salute San Raffaele, Milan, Italy.
  • Risitano AM; AORN San Giuseppe Moscati, Hematology and Hematopoietic Stem Cell Transplantation Unit, Avellino, Italy; Federico II University of Naples, Naples, Italy.
  • Calado RT; Department of Medical Imaging, Hematology and Clinical Oncology, University of São Paulo, Ribeirão Preto, School of Medicine, Brazil.
  • Lambris JD; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: lambris@pennmedicine.upenn.edu.
Clin Immunol ; 220: 108598, 2020 11.
Article em En | MEDLINE | ID: mdl-32961333
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Síndrome do Desconforto Respiratório / Complemento C3 / Complemento C5 / Infecções por Coronavirus / Inativadores do Complemento / Betacoronavirus / Fatores Imunológicos Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumonia Viral / Síndrome do Desconforto Respiratório / Complemento C3 / Complemento C5 / Infecções por Coronavirus / Inativadores do Complemento / Betacoronavirus / Fatores Imunológicos Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article