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Resistance to natural and synthetic gene drive systems.
Price, Tom A R; Windbichler, Nikolai; Unckless, Robert L; Sutter, Andreas; Runge, Jan-Niklas; Ross, Perran A; Pomiankowski, Andrew; Nuckolls, Nicole L; Montchamp-Moreau, Catherine; Mideo, Nicole; Martin, Oliver Y; Manser, Andri; Legros, Mathieu; Larracuente, Amanda M; Holman, Luke; Godwin, John; Gemmell, Neil; Courret, Cécile; Buchman, Anna; Barrett, Luke G; Lindholm, Anna K.
Afiliação
  • Price TAR; Department of Ecology, Evolution and Behaviour, University of Liverpool, Liverpool, UK.
  • Windbichler N; Department of Life Sciences, Imperial College London, London, UK.
  • Unckless RL; Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.
  • Sutter A; School of Biological Sciences, University of East Anglia, Norwich, UK.
  • Runge JN; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.
  • Ross PA; Bio21 and the School of Biosciences, The University of Melbourne, Parkville, Victoria, Australia.
  • Pomiankowski A; Department of Genetics, Evolution and Environment, University College London, London, UK.
  • Nuckolls NL; Stowers Institute for Medical Research, Kansas City, MO, USA.
  • Montchamp-Moreau C; UMR Evolution Génome Comportement et Ecologie, Université Paris-Saclay, CNRS, IRD, Gif sur Yvette, France.
  • Mideo N; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada.
  • Martin OY; Department of Biology (D-BIOL) & Institute of Integrative Biology (IBZ), ETH Zurich, Zurich, Switzerland.
  • Manser A; Department of Ecology, Evolution and Behaviour, University of Liverpool, Liverpool, UK.
  • Legros M; CSIRO Agriculture and Food, Canberra, ACT, Australia.
  • Larracuente AM; CSIRO Synthetic Biology Future Science Platform, Canberra, ACT, Australia.
  • Holman L; Department of Biology, University of Rochester, Rochester, NY, USA.
  • Godwin J; School of Biosciences, The University of Melbourne, Melbourne, Victoria, Australia.
  • Gemmell N; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.
  • Courret C; Department of Anatomy, University of Otago, Dunedin, New Zealand.
  • Buchman A; UMR Evolution Génome Comportement et Ecologie, Université Paris-Saclay, CNRS, IRD, Gif sur Yvette, France.
  • Barrett LG; CSIRO Synthetic Biology Future Science Platform, Canberra, ACT, Australia.
  • Lindholm AK; University of California, La Jolla, CA, USA.
J Evol Biol ; 33(10): 1345-1360, 2020 10.
Article em En | MEDLINE | ID: mdl-32969551
ABSTRACT
Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Evolução Biológica / Tecnologia de Impulso Genético Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Seleção Genética / Evolução Biológica / Tecnologia de Impulso Genético Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article