Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing.
Am J Health Syst Pharm
; 77(23): 1980-1985, 2020 11 16.
Article
em En
| MEDLINE
| ID: mdl-32974650
ABSTRACT
PURPOSE:
To determine the physical intravenous Y-site compatibility of 19 commonly used medications at pediatric concentrations with 3 different types of lipid emulsion.METHODS:
Medications at commonly used pediatric concentrations were mixed in a 11 ratio with lipid emulsions (Intralipid, Nutrilipid, and Smoflipid) and incubated at room temperature for 4 hours to simulate Y-site administration. Each sample was then diluted with particle-free water and analyzed using the analytical technique of light obscuration recommended in United States Pharmacopeia (USP) general information chapter 729 (USP <729>). Physical compatibility was determined by measuring the percentage of fat residing in globules larger than 5 µm (PFAT5) per USP <729> recommendations.RESULTS:
Most combinations tested were physically compatible based on USP <729> regulations. Incompatibilities differed for the different brands of lipid emulsion. The two combinations that met USP <729> criteria for physical incompatibility were cisatracurium 2 mg/mL with Intralipid and gentamicin 2 mg/mL with Smoflipid.CONCLUSION:
Three different lipid emulsions were physically compatible at the Y site with the majority of medications tested. Data regarding Y-site compatibility for one lipid emulsion product cannot be safely extrapolated to another without additional testing.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Emulsões Gordurosas Intravenosas
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article