<i>Cotinus coggygria</i> Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells.

Gospodinova, Zlatina I; Zupkó, Istvan; Bózsity, Noémi; Manova, Vasilissa I; Georgieva, Mariyana S; Todinova, Svetla J; Taneva, Stefka G; Ocsovszki, Imre; Krasteva, Maria E

Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells.

Gospodinova, Zlatina I; Zupkó, Istvan; Bózsity, Noémi; Manova, Vasilissa I; Georgieva, Mariyana S; Todinova, Svetla J; Taneva, Stefka G; Ocsovszki, Imre; Krasteva, Maria E.

Afiliação

Gospodinova ZI; Laboratory of Genome Dynamics and Stability, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.
Zupkó I; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos Str. 6, H-6720 Szeged, Hungary.
Bózsity N; Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eotvos Str. 6, H-6720 Szeged, Hungary.
Manova VI; Laboratory of Genome Dynamics and Stability, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.
Georgieva MS; Laboratory of Regulation of Gene Expression, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.
Todinova SJ; Department of Biomacromolecules and Biomolecular Interactions, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.
Taneva SG; Department of Biomacromolecules and Biomolecular Interactions, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.
Ocsovszki I; Department of Biochemistry, University of Szeged, Dóm tér 9, H-6720 Szeged, Hungary.
Krasteva ME; Laboratory of Genome Dynamics and Stability, Institute of Plant Physiology and Genetics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bldg. 21, 1113 Sofia, Bulgaria.

Z Naturforsch C J Biosci ; 76(3-4): 129-140, 2021 Mar 26.

Article em En | MEDLINE | ID: mdl-32975208

Assuntos

Anacardiaceae/química; Neoplasias da Mama/tratamento farmacológico; Proliferação de Células/efeitos dos fármacos; Extratos Vegetais/farmacologia; Apoptose/efeitos dos fármacos; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Pontos de Checagem do Ciclo Celular/efeitos dos fármacos; DNA (Citosina-5-)-Metiltransferase 1/genética; DNA (Citosina-5-)-Metiltransferases/genética; Dano ao DNA/efeitos dos fármacos; DNA Metiltransferase 3A; Proteínas de Ligação a DNA/genética; Epigênese Genética/efeitos dos fármacos; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Células MCF-7; Extratos Vegetais/química; Folhas de Planta/química

Palavras-chave

Cotinus coggygria Scop.; MCF7 breast cancer cell line; anticancer effect; molecular mechanisms

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Extratos Vegetais / Anacardiaceae / Proliferação de Células Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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