Antiphospholipid Antibody and Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis.
Stroke
; 51(12): 3728-3732, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-32981458
ABSTRACT
BACKGROUND AND PURPOSE:
Although aPLs (antiphospholipid antibodies) are associated with thrombotic events, especially in young patients, the role of aPLs in recurrent ischemic strokes (RIS) is unclear. This systematic review and meta-analysis evaluated the association between aPLs and RIS.METHODS:
The systematic review was conducted by a computer-assisted search of literature in PubMed, EMBASE, and Cochrane library published in English or Korean from 1990, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA). Review Manager 5.3 software was used for statistical analyses.RESULTS:
Of the 2272 identified articles, 8 studies were included (2510 subjects; 844 aPL positive). The meta-analysis revealed a relative risk of aPLs for RIS of 1.41 (95% CI, 0.91-2.17; I2=54%). In the subgroup analysis, age <50 years, ethnicity, and type of aPL did not increase the risk of RIS.CONCLUSIONS:
We found that aPLs are not an independent predictor for RIS in adults. However, considering the nonstandardized disease criteria, further well-designed prospective trials should be considered to confirm these findings.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anticorpos Antifosfolipídeos
/
AVC Isquêmico
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article