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Antiphospholipid Antibody and Recurrent Ischemic Stroke: A Systematic Review and Meta-Analysis.
Kim, Yerim; Kim, Soo Young.
Afiliação
  • Kim Y; Department of Neurology (Y.K.), Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
  • Kim SY; Department of Family Medicine (S.Y.K.), Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea.
Stroke ; 51(12): 3728-3732, 2020 12.
Article em En | MEDLINE | ID: mdl-32981458
ABSTRACT
BACKGROUND AND

PURPOSE:

Although aPLs (antiphospholipid antibodies) are associated with thrombotic events, especially in young patients, the role of aPLs in recurrent ischemic strokes (RIS) is unclear. This systematic review and meta-analysis evaluated the association between aPLs and RIS.

METHODS:

The systematic review was conducted by a computer-assisted search of literature in PubMed, EMBASE, and Cochrane library published in English or Korean from 1990, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA). Review Manager 5.3 software was used for statistical analyses.

RESULTS:

Of the 2272 identified articles, 8 studies were included (2510 subjects; 844 aPL positive). The meta-analysis revealed a relative risk of aPLs for RIS of 1.41 (95% CI, 0.91-2.17; I2=54%). In the subgroup analysis, age <50 years, ethnicity, and type of aPL did not increase the risk of RIS.

CONCLUSIONS:

We found that aPLs are not an independent predictor for RIS in adults. However, considering the nonstandardized disease criteria, further well-designed prospective trials should be considered to confirm these findings.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Antifosfolipídeos / AVC Isquêmico Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anticorpos Antifosfolipídeos / AVC Isquêmico Tipo de estudo: Etiology_studies / Prognostic_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article