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Biomarkers of the early response to treatment of visceral leishmaniasis: A prospective cohort study.
S Lima, Simone; Cavalcante Braz, Débora; Costa Silva, Vladimir; J C Farias, Teresinha; Zacarias, Danielle Alves; da Silva, Jailthon Carlos; Costa, Carlos Henrique Nery; Costa, Dorcas Lamounier.
Afiliação
  • S Lima S; Maternal and Childhood Department, Federal University of Piauí, Teresina, Brazil.
  • Cavalcante Braz D; Pharmacy Course, Federal University of Piauí, Teresina, Brazil.
  • Costa Silva V; Laboratory of Leishmaniasis, Natan Portella Institute of Tropical Medicine, Teresina, Brazil.
  • J C Farias T; Laboratory of Leishmaniasis, Natan Portella Institute of Tropical Medicine, Teresina, Brazil.
  • Zacarias DA; Intelligence Center for Emerging and Neglected Tropical Diseases (CIATEN), Teresina, Brazil.
  • da Silva JC; Laboratory of Leishmaniasis, Natan Portella Institute of Tropical Medicine, Teresina, Brazil.
  • Costa CHN; Laboratory of Leishmaniasis, Natan Portella Institute of Tropical Medicine, Teresina, Brazil.
  • Costa DL; Laboratory of Leishmaniasis, Natan Portella Institute of Tropical Medicine, Teresina, Brazil.
Parasite Immunol ; 43(1): e12797, 2021 01.
Article em En | MEDLINE | ID: mdl-32984951
BACKGROUND: Early biomarkers of the response to treatment are lacking and may help to reduce mortality by the vector-borne disease visceral leishmaniasis (VL). METHODS: A prospective cohort study was conducted to investigate plasma cytokines and clinical laboratory data as biomarkers of the early response to specific treatment for VL in 36 patients. RESULTS: The mean interleukin 6 (IL-6) concentration on the 7th day was 2.3% of the pre-treatment concentration, interleukin 10 (IL-10) was 8.0%, and interleukin 8 (IL-8) was 8.2%. On the 7th day, IL-10 was below half of the pre-treatment concentration in 100.0%, IL-8 in 95.5% and IL-6 in 90.9%. The spleen and liver sizes, haemoglobin, interleukin 1 beta (IL-1ß) and tumour necrosis factor alpha (TNF-α) showed a slower recovery. Fever disappeared in 91% on the 7th day, 69.4% had a normal white cell count, and 77.8% had a normal platelet value by this time. CONCLUSIONS: The plasma cytokines IL-6, IL-10 and IL-8 were demonstrated to be excellent markers of the early response to VL treatment and if tested before the 7th day, will likely prove to be better than fever measurement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-8 / Interleucina-6 / Interleucina-10 / Leishmaniose Visceral Tipo de estudo: Etiology_studies / Observational_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-8 / Interleucina-6 / Interleucina-10 / Leishmaniose Visceral Tipo de estudo: Etiology_studies / Observational_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2021 Tipo de documento: Article