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Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors.
Shen, Jian; Deng, Xinxian; Sun, Ran; Tavallaie, Mojdeh S; Wang, Juntao; Cai, Qingqing; Lam, Celine; Lei, Shuwen; Fu, Lei; Jiang, Faqin.
Afiliação
  • Shen J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China; Viva Biotech Ltd. (Shanghai), No. 334 Aidisheng Rd., Pudong District, Shanghai, 201203, PR China.
  • Deng X; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Sun R; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Tavallaie MS; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Wang J; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Cai Q; Department of Pharmacy, Fudan University Affiliated Zhongshan Hospital, No. 250 Xiaomuqiao Rd. Shanghai, 200032, Xuhui District, Shanghai, PR China.
  • Lam C; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Lei S; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China.
  • Fu L; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China. Electronic address: leifu@sjtu.edu.cn.
  • Jiang F; Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, No. 800 Dongchuan Rd. Minhang District, Shanghai, 200240, PR China. Electronic address: jfq2008@sjtu.edu.cn.
Eur J Med Chem ; 208: 112850, 2020 Dec 15.
Article em En | MEDLINE | ID: mdl-32987315
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Dipeptidil Peptidase 4 / Diabetes Mellitus Experimental / Inibidores da Dipeptidil Peptidase IV / Hipoglicemiantes Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Pirimidinas / Dipeptidil Peptidase 4 / Diabetes Mellitus Experimental / Inibidores da Dipeptidil Peptidase IV / Hipoglicemiantes Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article