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Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain.
Huang, Ping-Han; Tsai, Hsiao-Han; Liao, Bo-Hung; Lin, Yi-Ling; Jan, Jia-Tsrong; Tao, Mi-Hua; Chou, Yu-Chi; Hu, Che-Ming Jack; Chen, Hui-Wen.
Afiliação
  • Huang PH; Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
  • Tsai HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Liao BH; Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.
  • Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Jan JT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Tao MH; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Chou YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Hu CJ; RNAi Core Facility, Academia Sinica, Taipei, Taiwan.
  • Chen HW; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hum Vaccin Immunother ; 17(3): 654-655, 2021 03 04.
Article em En | MEDLINE | ID: mdl-32991231
A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligação Proteica / Anticorpos Neutralizantes / Domínios Proteicos / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ligação Proteica / Anticorpos Neutralizantes / Domínios Proteicos / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Limite: Animals / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article